Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every four months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type, Setting, and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea Pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic, and only publications dated 2020 or later (with some exceptions) can be filtered by Setting. Most publications older than 2010 can only be searched by keyword. 

The ways in which humans can support good welfare for animals in their care is an ongoing subject of debate: some place emphasis on the animals’ physical health; others, on animals’ ability to live “natural...

Animal behaviour and, as a result, animal welfare are increasingly complex areas of study, with the diversity of the animal kingdom and new research findings ensuring there is no one, easy answer. Instead, we need...

The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and...

The performance of natural behavior is commonly used as a criterion in the determination of animal welfare. This is still true, despite many authors having demonstrated that it is not a necessary component of welfare...

Modern day zoos and aquariums continuously assess the welfare of their animals and use evidence to make informed management decisions. Historically, many of the indicators of animal welfare used to assess the collection are negative...

This ethical discourse specifically deals with dilemmas encountered within zoological institutions, namely for the concept of natural living, and a new term—wilding. It is agreed by some that zoos are not ethically wrong in principle...

This article describes the importance of providing laboratory animals with opportunities to engage in play, and provides a few practical ideas for how to do this.

Although most abnormal behaviors, including all stereotypies, indicate poor welfare, some that occur in rare situations are functional and do not indicate a negative situation. There is a wide range of abnormal behaviors that occur...

This is the Second Edition of a well-received book that reflects a fresh, integrated coverage of the concepts and scientific measurement of stress and welfare of animals including humans. This book explains the basic biological...

This second edition is fully revised, expanded, and comprehensively updated with the most current knowledge about the full array of mental health issues seen in animals. Written by key opinion leaders, internationally-recognized experts and specialists...

In nature, animals need to actively engage with the environment in order to prosper in survival and reproduction. Hence, agency is a central adaptive characteristic of animal life. In this paper, I propose that from...

The field of zoo animal welfare science has developed significantly over recent years. However despite this progress in terms of scientific research, globally, zoo animals still face many welfare challenges. Recently, animal welfare frameworks such...

Naturalness is considered important for animals, and is one criterion for assessing how we care for them. However, it is a vague and ambiguous term, which needs definition and assessments suitable for scientific and ethical...

A basic assumption of most researchers is that behavior is generally functional, and indeed, in most instances the function is obvious. But in a number of cases, some behaviors of neurophysiologically ‘normal’ organisms appear to...

Many biomedical research studies use captive animals to model human health and disease. However, a surprising number of studies show that the biological systems of animals living in standard laboratory housing are abnormal. To make...

This is a report of a one-day meeting jointly convened by the RSPCA and the Animal and Plant Health Agency (APHA), which brought together around 70 researchers, veterinarians, animal technologists, regulators and others with an...

Performance of abnormal repetitive behavior (ARB) is noted in many captive wild species. ARB can be categorized into 2 basic forms: those whose aim appears to be to compulsively reach an inappropriate goal and those...

There is no consensus regarding the functions of play. As play behavior is a characteristic of young stages of development, it has been suggested that the higher prevalence of adult play observed in domestic animals...

Refinement typically is viewed as a means of reducing harms to animals used in laboratory research. Examples of recent research on refinement include improved methods of handling and euthanasia. Focus in the animal welfare literature...

Challenges are there to be overcome – seen usually as problems to avoid rather than as opportunities to enjoy. However, for humans a life without challenge would be likely to be dull and boring, lacking...

Normal behavior plays a key role in facilitating homeostasis, especially by allowing the animal to control and modify its environment. Captive environments may interfere with these behavioral responses, and the resulting stress may alter many...