Drug delivery in research on nonhuman animals in the laboratory is still challenging because it is usually invasive and stressful. Stress-free voluntary oral drug administration in water lacks precise control of dose and timing of...
Curcumin, a polyphenol derived from turmeric, has a wide variety of therapeutic benefits including antiinflammatory, antioxidative, and chemopreventative effects. Oral gavage is widely performed to administer curcumin in laboratory rodents in several experimental models. Although...
Orogastric gavage, while a common method for delivering experimental substances in mice, has been shown to induce stress. To minimize the associated stress with this procedure, sham gavage prior to the start of experiment is...
Twenty-six reports provide detailed information of how primates can be trained to voluntarily cooperate - rather than resist - during blood collection, injection, topical drug application, blood pressure measurement, urine collection, and capture.
The physiologic and anatomic structure of rabbits can cause high mortality rates in rabbit oral gavage. Rabbits are capable of a wide variety of jaw movement due to 3 jaw-closing muscle groups (masseter, temporalis, pterygoid)...
Many compounds are orally administered to laboratory rats using the gavage technique. This technique is stressful for the animal and can cause injury or death if performed incorrectly. Often compounds are suspended in food oils...
The RSPCA/UFAW Rodent Welfare Group holds a one-day meeting every autumn so that its members can discuss current welfare research, exchange views on rodent welfare issues and share experiences of the implementation of the 3Rs...
Guinea pigs are difficult to oral gavage dose. Previous adverse effects from this dosing method, using rigid catheters, had caused an earlier endpoint to studies and loss of data. We therefore developed a prototype gag...
Stress can influence a number of physiological processes including adult neurogenesis, metabolism, cardiovascular function, immune function, neurophysiological function, endocrine function and inflammatory processes following injury. In testing drugs which may be used to treat various...
A new application of a device enabling the long-term enteral administration of drugs or nutritional supplementation was developed for implementing in research entailing the use of macaques (Macaca fascicularis). After implanting a subcutaneous port, a...