Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every four months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type, Setting, and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea Pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic, and only publications dated 2020 or later (with some exceptions) can be filtered by Setting. Most publications older than 2010 can only be searched by keyword. 

The soft‐bodied cephalopods including octopus, cuttlefish, and squid are broadly considered to be the most cognitively advanced group of invertebrates. Previous research has demonstrated that these large‐brained molluscs possess a suite of cognitive attributes that...

This great cool-down snack is ideal for group or singly housed swine or nonhuman primates (particularly in larger pen-style housing). This item can be customized for canines as well by modifying the liquid used and/or...

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of...

In order to assess the extent to which the legally prescribed training for the acquisition of animal experimentation expertise provides scientific personnel with the necessary competence and expertise to carry out a correct harm-benefit analysis...

Quantitative blood pressure measurement is a critical parameter for assessing cardiovascular health, monitoring physiologic status under anesthesia, and making clinical decisions. The placement of an arterial catheter is the most accurate way to measure blood...

Cephalopods are increasingly viewed as sentient animals that require the same welfare consideration as their vertebrate counterparts. In this study, an observational welfare assessment tool developed by the EU Directive was revised to be species-specific...

Regardless of the microbiological status of an animal facility, research animals may experience health problems, leading to pain, suffering and distress. Simple and efficient tools are needed to collect data systematically, allowing researchers to react...

This DIY snack is great for NHP and can be customized in a variety of ways.

This simple DIY training treat is great for NHP, swine, rabbits, rodents, and dogs. Note that dehydrated watermelon may resemble muscle tissue!

One of our colony’s five guinea pigs started to develop a moderate case of pododermatitis (bumblefoot) on one paw, which staff were keen to alleviate to prevent any detrimental effects that this might have on...

The assessment and understanding of Absorption, Distribution, Metabolism and Elimination (ADME) for new pharmaceuticals is required in regulatory submissions. Typically, ADME studies are conducted using metabolism cages designed for the single housing of animals to...

There are several items we often use in animal facilities that when finished with are thrown away. However, many of these items come in packaging that can be recycled as enrichment for our animals, particularly...

There are a multitude of health monitoring techniques/ methods available. It can be difficult to know which of these to use and when to use them. This is an attempt to simplify, maximise the efficacy...

A top priority of modern zoos is to ensure good animal welfare (AW), thus, efforts towards improving AW monitoring are increasing. Welfare assessments are performed through more traditional approaches by employing direct observations and time-consuming...

Cephalopods are important in biologic and biomedical research, yet relatively little objective information is available to guide researchers and veterinarians regarding the best methods for anesthetizing these animals for various experimental procedures. Recent studies demonstrate...

Environmental enrichment is a common tool used in zoo and aquarium settings to provide mental and physical stimulation to animals under human care. This paper aims to present a primary approach to goal-oriented environmental and...

This article describes the ingredients, supplies, and directions to make this DIY hanging item, which is great for NHP and swine.

This article describes the ingredients and directions to make this simple DIY destructible enrichment for NHP and swine.

Octopus cyanea has a wide range of natural distribution and is interesting for scientific research. However, unlike Octopus vulgaris, the species is poorly studied, and few data exist on best practices for keeping them. One...

While non-human primate studies have long been conducted in laboratories, and more recently at zoological parks, sanctuaries are increasingly considered a viable setting for research. Accredited sanctuaries in non-range countries house thousands of primates formerly...

Little research has been carried out into how guinea pigs are cared for in the UK, and information regarding potential welfare issues is sparse. This study was designed to examine the five welfare needs, collecting...

Research in ecology and wildlife biology remains crucial for increasing our knowledge and improving species management and conservation in the midst of the current biodiversity crisis. However, obtaining information on population status often involves invasive...

Shelters are important for animal survival. Provision of adequate hiding places allow animals to express their natural sheltering behavior and it can have different positive effects on cortisol levels, physiological processes and mental performance. Although...

Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of working with these animals in research. Appropriate treatment of pain in laboratory rodents requires accurate assessments of the presence or absence of...