Refinement Database

Database on Refinement of Housing, Husbandry, Care, and Use of Animals in Research

This database, created in 2000, is updated every four months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research.

Tips for using the database:

  • This landing page displays all of the publications in the database.
  • Use the drop-down menus to filter these publications by Animal Type, Setting, and/or Topic.
  • Clicking on a parent category (e.g., Rodent) will include publications relating to all the items in that category (e.g., Chinchilla, Gerbil, Guinea Pig, etc.).
  • You may also add a keyword to further narrow your search.
  • Please note that at this time, only publications dated 2010 or later (with some exceptions) can be filtered by Animal Type and Topic, and only publications dated 2020 or later (with some exceptions) can be filtered by Setting. Most publications older than 2010 can only be searched by keyword. 

This DIY snack is great for NHP and can be customized in a variety of ways.

This simple DIY training treat is great for NHP, swine, rabbits, rodents, and dogs. Note that dehydrated watermelon may resemble muscle tissue!

There are several items we often use in animal facilities that when finished with are thrown away. However, many of these items come in packaging that can be recycled as enrichment for our animals, particularly...

Playing music or natural sounds to animals in human care is thought to have beneficial effects. An analysis of published papers on the use of human-based music with animals demonstrates a variety of different results...

Whether animals have emotions was historically a long-lasting question but, today, nobody disputes that they do. However, how to assess them and how to guarantee animals their welfare have become important research topics in the...

This article describes the ingredients, supplies, and directions to make this DIY hanging item, which is great for NHP and swine.

This article describes the ingredients and directions to make this simple DIY destructible enrichment for NHP and swine.

Tamarins and marmosets are small-bodied social callitrichines. Wild callitrichines feed on exudates, such as sap and gum; particularly, marmosets are mainly gummivores, while tamarins consume gums only occasionally and opportunistically. Zoo marmosets and tamarins are...

This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows...

Boredom, while often casually attributed to non-human animals by both laypeople and scientists, has received little empirical study in this context. It is sometimes dismissed by others as anthropomorphic or a trivial concern in comparison...

Human body odors contain chemosignals that make species-specific communication possible. Interspecies communication studies were conducted on dogs and horses subjected to human chemosignals produced in happiness and fear emotional states. Dogs showed behaviors consistent with...

This article describes the importance of providing laboratory animals with opportunities to engage in play, and provides a few practical ideas for how to do this.

Measuring body surface temperature changes with infrared thermography has recently been put forward as a non-invasive alternative measure of physiological correlates of emotional reactions. In particular, the nasal region seems to be highly sensitive to...

This second edition is fully revised, expanded, and comprehensively updated with the most current knowledge about the full array of mental health issues seen in animals. Written by key opinion leaders, internationally-recognized experts and specialists...

Behavioral management programs aim to enhance the welfare of animal subjects that participate in research, thereby enhancing our ability to conduct ethical research projects. Socialization strategies, environmental enrichment techniques, opportunities for subjects to voluntarily participate...

In nature, animals need to actively engage with the environment in order to prosper in survival and reproduction. Hence, agency is a central adaptive characteristic of animal life. In this paper, I propose that from...

Scientists are often reluctant to attribute emotions to nonhuman animals that are similar to human emotions. When the author published her early studies, reviewers prohibited the word fear. Fearful behavior had to be described as...

Innovations in apparatus technology come about for a variety of reasons such as the need to use the same methodology with various species, the opportunity to present dynamic and carefully controlled stimuli, the goal of...

This article describes creative enrichment ideas for nonhuman primates, including celery stalks embedded with seeds; paper rolled into tubes, braided and filled with fruit and seeds; pineapple crowns loaded with treats; dry spaghetti noodles coated...

As a large institution housing a variety of species, providing meaningful enrichment to all animals can be an expensive endeavor. Additionally, animal care staff already has a full schedule of responsibilities, including daily animal health...

Laboratory animals experience a large amount of environmental stress. An animal’s environment can include both physiological and social stressors that may require an animal to adapt to maintain allostatic balance. For example, thermal stress can...

It is widely known that the psychological wellbeing of captive animals can become compromised by a captive environment that lacks proper environmental stimulation. Environmental enrichment programs have become the norm in captive environments yet research...

Environmental enrichment in zoos and aquariums is often evaluated at two overlapping levels: published research and day‐to‐day institutional record keeping. Several authors have discussed ongoing challenges with small sample sizes in between‐groups zoological research and...

"Do any of you give cooked food like pasta, potatoes or vegetables to non-human primates? What’s your experience? Do the animals benefit from cooked food; do they like it; does it affect their health in...

More than a quarter of a century has elapsed since the Animal Welfare Act mandated that research facilities develop and follow a plan to promote the psychological well-being of captive primates. Since passage of this...